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. 2021 Feb 7;6(7):4656–4662. doi: 10.1021/acsomega.0c05352

Figure 5.

Figure 5

As expected, acetaminophen (300 mg/kg) caused an acute increase in serum ALT levels in wild-type female C57BL/6 mice treated with acetaminophen (300 mg/kg) at 0 and 48 h. Increases were seen on day 1 after the initial dose of acetaminophen, and this elevation in ALT levels decreased on days 2 and 3. A second dose of acetaminophen on day 2 did not produce an increase in ALT levels. The data represent the mean ± SEM, and statistical significance was tested using a one-way ANOVA with Tukey’s multiple comparisons test; *p < 0.05 (n = 3 mice/group).