Figure 7.

H&E-stained histology samples of the liver (10× magnification) in wild-type and PD-1^–/– animals. In both groups treated with AQ in the PD-1^–/– animals, there is evidence of infiltrating lymphocytes surrounding the central vein/portal triad. Areas typical of acetaminophen-induced necrosis with variable amounts of inflammatory infiltrates and early repair in zone 3 regions were observed. No differences were seen between the single and two doses of acetaminophen; therefore, the last pane displays the results from two acetaminophen doses. The bulk of the inflammatory foci appears to be in the transitional and pericentral (zones 2 and 3) regions of the liver section.