TABLE 3.

Univariate and multivariate analysis in incident patients

Model 1	Univariate		Multivariate
	Scaled hazard ratio	p-value	Scaled hazard ratio	p-value
Model 1
Age	2.063	<0.0001	2.177	<0.0001
Gender (ref. female)	1.316	0.054
CTD-PAH (ref. (I/D/H)PAH)	1.336	0.031	1.444	0.017
WHO functional class III (ref. class I and II)	1.817	0.009
WHO functional class IV (ref. class I and II)	3.642	<0.0001	2.978	<0.0001
Mean RAP	1.196	0.006	1.227	0.005
Cardiac index	0.756	0.001
Model 2
Age	2.063	<0.0001	2.180	<0.0001
Gender (ref. female)	1.316	0.054
CTD-PAH (ref. (I/D/H)PAH)	1.336	0.031
WHO functional class III (ref. class I and II)	1.817	0.009
WHO functional class IV (ref. class I and II)	3.642	<0.0001
Mean RAP	1.196	0.006
Cardiac index	0.756	0.001
EmPHasis-10 score	1.518	<0.0001	1.447	<0.0001
Model 3
Age	2.063	<0.0001	1.860	<0.0001
Gender (ref. female)	1.316	0.054
CTD-PAH (ref. (I/D/H)PAH)	1.336	0.031
WHO functional class III (ref. class I and II)	1.817	0.009
WHO functional class IV (ref. class I and II)	3.642	<0.0001
Mean RAP	1.196	0.006
Cardiac index	0.756	0.001
EmPHasis-10 score	1.518	<0.0001	1.226	0.047
Walk distance#	0.461	<0.0001	0.574	<0.0001

PAH: pulmonary arterial hypertension; CTD: connective tissue disease; IPAH: idiopathic PAH; DPAH: drug-induced PAH; HPAH: heritable PAH; CTD-PAH: CTD-associated PAH; WHO: World Health Organization; RAP: right-atrial pressure. ^#: two types of walking test were used, the 6-min walk test (6MWT) and the incremental shuttle walk test (ISWT). For Cox regression modelling, distances were converted to a z-score and combined.