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De novo ceramide synthesis pathway and known inhibitors shown to improve metabolic diseases. Schematic of the de novo ceramide biosynthesis pathway highlighting the key enzymes involved in ceramide biosynthesis and their respective inhibitors. Abbreviations: ASAH1, acid ceramidase; CERS, ceramide synthase; DES, dihydroceramide desaturase; KDSR, 3-ketodihydrosphingosine reductase; SPT, serine palmitoyltransferase; UGCG, UDP-glucose ceramide glucosyltransferase.
