Figure 1.

Schematic showing design synergies between materials’ physiochemical properties and biological environments. Biomaterials varying in shape and size from centimeters to nanometers can be applied in tissue/cell environments having structural features across similar length scales, while also expressing various cues able to be recognized by endogenous stimuli-responsive materials (including enzymes, pH, redox, glucose, hypoxia, ATP, and nucleic acids).