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Application of pH-responsive polymer nanoparticles in pain management. (a) Schematic of pH-responsive polymer nanoparticles (from P(PEGMA-co-DMAEMA) shell blocks and P(DIPMA-co-DEGMA) or P(BMA) core-forming blocks) which target the neurokinin 1 receptor in endosomes to treat chronic pain. (b) Particle characterization data. (c) Particle TEM images. (d) Particle pH-responsive behavior characterization. Reproduced with permission from ref (175). Copyright 2019 Springer Nature.
