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. 2021 Feb 8;15(2):2068–2098. doi: 10.1021/acsnano.0c09115

Figure 5.

Figure 5

Application of cathepsin B in theranostic responsive systems. (A) Designed FRET imaging response of polymer conjugate on exposure to enzyme cathepsin B (papain). (B) Cy5 FRET ratio of conjugate when incubated with different concentrations of papain. (C) Cy5 FRET ratio change over time (4 h with 5 × 10–6 M papain). (D) In vivo FRET imaging of mice bearing A2780 human ovarian tumor after intravenous administration of polymer conjugate. Reproduced with permission from ref (102). Copyright 2017 Wiley VCH.