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Tumor microenvironment-targeted delivery of antimiRs using a peptide with a low-pH-induced transmembrane structure (pHLIP). Distribution of pHLIP labeled with Alexa Fluor 750, 36 h after systemic administration to (a) nude mouse with miR-155 flank tumors and (b) mouse with lymphadenopathy. (c) Schematic of pHLIP-mediated antimiR delivery. Reproduced with permission from ref (128). Copyright 2015 Springer Nature.
