Figure 3.

Detection of the ODN-modified specific sequence motifs on DNA using nanopores. (a) Schematic of the translocation of the labeled DNA through a nanopore. The red marks represent the seven ODN-labeled sites. (b) Recorded current trace at 400 mV with each spike signal representing a single DNA molecule translocation. (c) Examples of the translocation signals. The DNA entered the nanopore in two orientations, with site 1 or site 7 first entering the nanopore, respectively. The additional spikes marked with numbers represent signals caused by the ODN labels on the seven sites.