Table 2.
Lead SNPs Associated with CVD at Genome-wide Significance by GWAS
| SNP | Position | Locus | Clustered SNPs | M/m | MAF | 1000GenomeFreq Frequency |
Genes | Feature | CAD | IS | CCD | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asian | Eur | Amer | OR | P | OR | P | OR | P | |||||||||
| HTN | rs1550676 | 17:77,801,055 | 17q25.3 | rs74608211, rs145216691, rs559385953 | T/C | 0.01176 | – | – | – |
CBX8-CBX4, CBX2 GAA CARD14 SLC26A11 |
Intergenic | 2.607 (1.886–3.602) | 6.37E−09 | 0.5929 (0.2625–1.339) | 2.09E−01 | 1.927 (1.417–2.621) | 2.90E−05 |
| DM | rs149608518 | 4:165,472,675 | 4q32.3 | – | C/T | 0.01035 | 0.0079 | 0 | 0 |
MARCH1-LINC01207, APELA |
Intergenic | 1.425 (0.7313–2.775) | 2.98E−01 | 5.587 (3.086–10.12) | 1.34E−08 | 2.68 (1.639–4.384) | 8.55E−05 |
| rs139293840 | 17:78,530,359 | 17q25.3 | rs957271283, rs147509862 | G/A | 0.01013 | 0.0089 | 0.001 | 0 |
RPTOR, RNF213 CARD14 SLC26A11 |
Intron | 3.359 (2.058–5.484) | 1.27E−06 | 3.111 (1.581–6.124) | 1.02E−03 | 3.511 (2.265–5.444) | 1.99E−08 | |
| DL | rs189668056 | 2:38,308,827 | 2p22.2 | rs189258819 | G/A | 0.02031 | 0.0129 | 0 | 0.0187 |
CYP1B1- CYP1B1-AS1 |
Intergenic | 1.942 (1.453–2.596) | 7.30E−06 | 2.147 (1.401–3.292) | 4.55E−04 | 2.027 (1.574–2.609) | 4.24E−08 |
| rs3897976 | 3:41,606,692 | 3p22.1 | – | G/A | 0.05095 | 0.0823 | 0.1074 | 0.1153 |
ULK4, CTNNB1 |
Intron | 1.008 (0.801–1.269) | 9.46E−01 | 2.162 (1.646–2.84) | 2.97E−08 | 1.301 (1.083–1.562) | 4.86E−03 | |
| rs79166762 | 9:92,466,006 | 9q22.2 | rs12115796, rs12115684, rs12115802, rs75847266, rs117445944, rs75273685, rs76097735, rs78819980, rs79641632 | T/C | 0.01918 | 0.0159 | 0 | 0 |
UNQ6494- LOC101927847, GADD45G SEMA4D |
Intergenic | 2.282 (1.724–3.019) | 7.78E−09 | 1.207 (0.6891–2.114) | 5.11E−01 | 1.928 (1.483–2.505) | 9.17E−07 | |
Lead SNPs were selected within genome-wide significant variants by lowest p-values. Genes include positional candidate genes within 400 kb of SNP, and initial mapped gene or genetic region is listed first before a comma. Odds ratios are shown as odds ratio (95% confidence interval). SNP, single nucleotide polymorphism; M/m, Major/minor allele; MAF, minor allele frequency; OR, odds ratio; P, p-value