. 2021 Feb 25;8:8. doi: 10.1186/s40673-021-00130-8

Table 3.

Interventions, results and GRADE of studies included in the review

Author/year	Interventions	Relevant statistical data	Grade
Dongmei et al., 2011 [19]	UCMSCs (1 × 10⁶ /kg; 10 mL) with 5 mg dexamethasone was injected intrathecally weekly for 4 weeks by lumbar punctures, resulting in 4 injections for 4 weeks.	ICARS = ↑ posture, gait disorders, coordination, speech disorders, ocular motility. ADL = ↑ self-care ability.	⊕ ⊕ ϴϴ Low
Jin et al., 2013 [20]	UCMSCs (4 × 10⁷) in 30 ml saline solution IV in 30 min and 3 treatments, 2 × 107 in 30 ml IV and 2 × 107 in 1 ml IT simultaneously. 4 applications a week apart.	After the first application of UCMSCs, 38% (6/16) ↑ BBS. From 3 to 6 months 63% (10/16) ↑ BBS and there were statistically significant improvements over the baseline. After 1-year 7/16 (44%) ↑ BBS over the baseline, and only 5/16 (31%) of the patients suffered from the disease. ↑ ICARS in the 3rd and 6th month.	⊕ ⊕ ϴϴ Low
Tsai et al., 2017 [21]	100 g of adipose tissue was collected by liposuction of the abdominal region of two healthy donors. The AD-MSC were frozen at a concentration of 7 × 107 viable cells in 20 ml of cryopreservation solution. On the day of infusion, thawed AD-MSCs were mixed with 100 ml with normal saline and administered IV in 40 min.	SARA score evolution: 13.25 at the baseline, 13.0 in the first 15 days, 12.75 at 6 months, and 13.5 at 12 months.	⊕ ⊕ ϴϴ Low

Author/year

Interventions

Relevant statistical data

Grade

Dongmei et al., 2011 [19]

UCMSCs (1 × 10⁶ /kg; 10 mL) with 5 mg dexamethasone was injected intrathecally weekly for 4 weeks by lumbar punctures, resulting in 4 injections for 4 weeks.

ICARS = ↑ posture, gait disorders, coordination, speech disorders, ocular motility. ADL = ↑ self-care ability.

⊕ ⊕ ϴϴ

Low

Jin et al., 2013 [20]

UCMSCs (4 × 10⁷) in 30 ml saline solution IV in 30 min and 3 treatments, 2 × 107 in 30 ml IV and 2 × 107 in 1 ml IT simultaneously. 4 applications a week apart.

After the first application of UCMSCs, 38% (6/16) ↑ BBS. From 3 to 6 months 63% (10/16) ↑ BBS and there were statistically significant improvements over the baseline. After 1-year 7/16 (44%) ↑ BBS over the baseline, and only 5/16 (31%) of the patients suffered from the disease. ↑ ICARS in the 3rd and 6th month.

⊕ ⊕ ϴϴ

Low

Tsai et al., 2017 [21]

100 g of adipose tissue was collected by liposuction of the abdominal region of two healthy donors. The AD-MSC were frozen at a concentration of 7 × 107 viable cells in 20 ml of cryopreservation solution. On the day of infusion, thawed AD-MSCs were mixed with 100 ml with normal saline and administered IV in 40 min.

SARA score evolution: 13.25 at the baseline, 13.0 in the first 15 days, 12.75 at 6 months, and 13.5 at 12 months.

⊕ ⊕ ϴϴ

Low

UCMSC Umbilical cord mesenchimal stem cells, ICARS Intarnational Cooperative Ataxia Rading Scale, ADL Activity of Daily Living Scale, IT Intrathecal, BBS Berg Balance Scale, AD-MSCs Adipose tissue mesenchimal stem cells, IV Intravenous, SARA Scale for the Assessment and Randing of Ataxia