Table 2.

Putative pathomechanisms and therapeutic agents in radiation nephropathy

Putative pathomechanisms	Putative therapeutic agents	Species	Sources
Oxidative Stress	N-Acetylcystein Atorvastatin Montelukast	Mouse, rat	Supporting evidence: [68–71] Opposing evidence: [72–75]
Renin–angiotensin–aldosterone system (RAAS)	ACE-inhibitors Aldosterone-antagonists	Human, mouse, rat	[76–82]
Cellular senescence (CS)		Rat	[83]
Inflammation	Montelukast	Mouse, tibet mini pigs, rabbits, primates	supporting evidence: [69, 84, 85] opposing evidence: [56, 57, 86, 87]
Fibrosis	ACE-inhibitors Epoxyeicosatrienoic acids	Human Mouse, primates	[76] [56, 69]
Vascular dysfunction	Epoxyeicosatrienoic acids	Human, mouse, rat	[88–91]