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. 2021 Feb 25;19:55. doi: 10.1186/s12951-021-00800-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Environmental sensitivity, inhibition of cell migration and biocompatibility of the NPs composed of different PEG-HA ratios. a Environmentally sensitive changes in particle size associated with mPEG and the o-HA block ratio. b Environmentally sensitive changes in zeta potential associated with mPEG and the o-HA block ratio. c Environmentally sensitive release profile of PTX from the NPs (upper, different pH environments; lower, different GSH environments). d Environmentally sensitive release profile of miR124 from the NPs (upper, different pH environments; lower, different GSH environments). e Effects of different treatments for 24 h (upper) and 48 h (lower) on the migration of MDA-MB-231 cells. (f) Biocompatibility of the NPs composed of the 3 materials in LO2 cells. *p < 0.05, **p < 0.01