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. 2021 Feb 25;19:55. doi: 10.1186/s12951-021-00800-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Characterization of PTX and miR124 coloaded CaP/LNS NPs. a The hydrodynamic size of the NPs was 187.4 ± 5.6 nm and the PDI was 0.138. b Zeta potential distribution of the NPs. The average potential of the NPs was -27.0 ± 3.5 mV. c TEM image of the NPs. d, e Changes in the hydrodynamic size (d) and zeta potential (e) of the NPs over 12 days in media with different pH values (7.4, 6.5, and 5.0) or GSH (20 mM, 2 mM, and 2 μM) concentrations. f, g Release profiles of miR124 (f) and PTX (g) from NPs in environments with different pH values or GSH concentrations