Table 1. Antiproliferative Activity against Androgen-Independent Prostate Cancer Cell Lines, DU145 and PC-3.
| cell lines/IC50 (μM)a |
cell lines/IC50 (μM)a |
||||
|---|---|---|---|---|---|
| compounds | DU145 | PC-3 | compounds | DU145 | PC-3 |
| 1 | >5 | >5 | 9 | 1.93 | >5 |
| 2 | 0.45 | 0.53 | 10 | >5 | >5 |
| 3 | 0.71 | 0.64 | 11 | 4.38 | >5 |
| 4 | 1.71 | 1.56 | 12 | 4.05 | 3.88 |
| 5 | >5 | >5 | 13 | 4.05 | >5 |
| 6 | 3.22 | 3.84 | 14 | 1.69 | 3.13 |
| 7 | >5 | >5 | 15 | >5 | >5 |
| 8 | >5 | >5 | |||
The concentration of compound that caused 50% reduction of cell growth relative to untreated cells determined by cell counting.