Table 3. Antiproliferative Activity of Compounds 2 and 3 against Other Tumor Cell Lines.
| cell
linea (IC50 μM)b |
|||||
|---|---|---|---|---|---|
| compounds | A549 | MDA-MB-231 | MCF-7 | KB | KB-VIN |
| 2 | 3.95 | 5.05 | 5.13 | 3.51 | 0.77 |
| 3 | 5.83 | 7.59 | 8.47 | 7.33 | 5.07 |
| paclitaxel (nM) | 4.90 | 6.78 | 10.94 | 5.24 | 1843.5 |
a
A549 (lung carcinoma), MDA-MB-231 (triple-negative breast cancer), MCF-7 (estrogen receptor-positive and HER2-negative breast cancer), KB (cervical cancer cell line HeLa derivative), KB-VIN (P-gp-overexpressing MDR subline of KB).
b
Antiproliferative activity expressed as IC50 values for each cell line, the concentration of compound that caused 50% reduction relative to untreated cells determined by the SRB assay.