Table 1. Inhibition of HDAC Activity and Cytotoxicity of the Synthesized Compounds against Several Cancer Cell Lines.

^aCalculated by ChemDraw 9.0 software.

^bConcentration (μM) of compounds that produces a 50% reduction in enzyme activity or cell growth; the numbers represent the averaged results from triplicate experiments.

^cCell lines: SW620, colon cancer; PC3, prostate cancer; NCI-H23, lung cancer.

^dSAHA, suberoylanilide acid, a positive control.

^eBelinostat, a positive control.