Table 8.
Common amino acids involved in the TMPSSR 2-ligand interaction.
| Drugs | Amino acids |
|---|---|
| Camostat mesylate (Reference drug) | ASP491, GLU289, ASN192, PHE357, MET488, PHE194, ILE242, PRO288 |
| Rosiglitazone (Antidiabetic drug) | PHE194, ILE242 |
| Mevastatin (Statin) | ILE242, PRO288, |
| Pitavastatin (Statin) | PHE357, PHE194, PRO288, ILE242 |
| Ezetimibe (Cholesterol lowering drug) | ASN192, GLU289, PHE194, ILE242 |
| Methyl prednisolone (Corticosteroid) | GLU289, ILE242, PHE194, PRO288, PHE357 |
| Danoprevir (Antiviral drug) | PHE357, PRO288 |
| Warfarin (Anticoagulant) | ASN192,PHE194,ILE242 |
| Dipyridamole/aspirin (Antiplatelet) | PHE357,ILE242,PRO288,PHE194, |
| Cilostazol (Antiplatelet) | GLU289, PHE194, ILE242, PRO288 |
| Pacritinib (Janus kinase inhibitor) | PHE357, PHE194, ILE242 |
| Tideglusib (Glycogen synthase kinase 3 inhibitor) | PHE357, PRO288 |
| Shikonin (Natural compound) | PHE357, PHE194, ILE242 |
| Epigallocatechin gallate (Flavonoid) | GLU289, ASN192, ASP491 |
| Fucosterol (Component of black cumin) | ILE242, PRO288, PHE194, PHE357 |
| Dithymoquinone (Component of black cumin) | ILE242, PRO288, PHE194, PHE357 |
| Campesterol (Plant sterol) | ILE242, PRO288, PHE357 |
| Gabexate mesylate (Reference drug) | PHE357, ALA243 |
| Danoprevir (Antiviral drug) | PHE357, ALA243 |
| Pacritinib (Janus kinase inhibitor) | PHE357, ALA243 |
| Tideglusib (Glycogen synthase kinase 3 inhibitor) | PHE357, ALA243 |
| Shikonin (Natural compound) | PHE357, ALA243 |
| Dithymoquinone (Component of black cumin) | PHE357, ALA243 |