Figure 5.

Deposits of C5b-9 in primary membranous nephropathy: examples of correlations with histological lesions and clinical characteristics. (A) The extent of staining of C5b-9 in the capillary wall is shown in relation with mesangial hypercellularity scored on scale from 0–3 in children with idiopathic membranous nephropathy (n = 16). The antibody used for staining was unspecified. Relations were tested with Spearman’s correlation (ρ). We plotted previously published individual data (87). (B) The extent of staining of C5b-9 in tubules is shown in relation with the number of leukocytes in the interstitium in patients with idiopathic membranous nephropathy (n = 27). (C) The extent of staining of C5b-9 in tubules is shown in relation with serum creatinine at the time of biopsy in patients with idiopathic membranous nephropathy (n = 27). Antibody aE11 was used for staining in both panels. Relations were tested with Pearson’s correlation (r). We reproduced both panels without adaptations from their previous publication with permission (112), ^© European Renal Association–European Dialysis and Transplant Association. (D) The extent of staining of C5b-9 in the capillary wall is shown in relation with the clinical outcome after 14-171 months of treatment in children with idiopathic membranous nephropathy (n = 16). The antibody used for staining was unspecified. The hazard ratio (HR) for kidney failure, proteinuria, or hematuria as compared with normal outcomes is given as estimated with Cox’s regression. We plotted previously published individual data (87).