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. 2021 Feb 11;11:599974. doi: 10.3389/fimmu.2020.599974

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Copyright © 2021 Koopman, van Essen, Rennke, de Vries and van Kooten

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deposits of C5b-9 in ANCA-associated vasculitis: examples of correlations with histological lesions and clinical characteristics. (A) The average staining intensity of C5b-9 in glomeruli is shown in relation with the percentage of glomeruli with mild mesangial hypercellularity and that with cellular crescents in patients with myeloperoxidase antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (n = 7). The antibody used for staining was unspecified. The correlation coefficient for mild mesangial hypercellularity is given; that for cellular crescents was nonsignificant. We plotted previously published individual data (116). (B) Staining intensity of C5b-9 in the glomerulus is shown in relation with histological patterns in patients with renal ANCA-associated vasculitis (n = 25). Antibody ab55811 was used for staining. Differences between staining intensities were tested with Fisher’s exact test. We plotted previously published individual data (53). (C) The average staining intensity of C5b-9 in glomeruli is shown in relation with serum creatinine at the time of biopsy in patients with myeloperoxidase antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (n = 7). The antibody used for staining was unspecified. We plotted previously published individual data (116). (D) The average staining intensity of C5b-9 in glomeruli is shown in relation with serum creatinine at the time of biopsy in patients with ANCA-negative pauci-immune crescentic glomerulonephritis (n = 12). The antibody used for staining was unspecified. We plotted previously published individual data (117). Relations were tested with Pearson’s correlation (r).