Table 1.
Patient characteristics
| Severance Set (n = 856) | SNUH Set (n = 107) | P-value (Severance vs SNUH) | TCIA Set (n = 203) | P-value (Severance vs TCIA) | |
|---|---|---|---|---|---|
| Age | 52.9 ± 15.4 | 50.9 ± 15.5 | 0.194 | 52.7 ± 14.9 | 0.818 |
| Sex | 0.721 | 0.305 | |||
| Male | 492 (57.5) | 64 (59.8) | 108 (53.2) | ||
| Female | 364 (42.5) | 43 (40.2) | 95 (46.8) | ||
| IDH status | >0.999 | <0.001 | |||
| Wildtype | 617 (72.1) | 77 (72.0) | 119 (58.6) | ||
| Mutation | 239 (27.9) | 30 (28.0) | 84 (41.4) | ||
| WHO grade | 0.005b | 0.054b | |||
| II | 175 (20.5) | 14 (13.1) | 48 (23.7) | ||
| IDH wildtype a | 37 (21.1) | 5 (35.7) | 3 (6.2) | ||
| IDH mutation + 1p/19 non-codeletion | 80 (45.7) | 1 (7.1) | 28 (58.3) | ||
| IDH mutation + 1p/19 codeletion | 58 (33.2) | 8 (57.2) | 17 (35.5) | ||
| III | 169 (19.7) | 35 (32.7) | 52 (25.6) | ||
| IDH wildtype | 89 (52.7) | 15 (42.9) | 17 (32.7) | ||
| IDH mutation + 1p/19 non-codeletion | 32 (18.9) | 12 (34.3) | 24 (46.2) | ||
| IDH mutation + 1p/19 codeletion | 48 (28.4) | 8 (22.8) | 11 (21.1) | ||
| IV | 512 (59.8) | 58 (54.2) | 103 (50.7) | ||
| IDH wildtype | 491 (95.9) | 57 (98.3) | 99 (96.1) | ||
| IDH mutation + 1p/19 non-codeletion | 16 (3.1) | 1 (1.7) | 3 (2.9) | ||
| IDH mutation + 1p/19 codeletion | 4 (0.8) | 0 (0.0) | 1 (1.0) | ||
| IDH mutation + 1p/19q status not specified | 1 (0.2) | 0 (0.0) | 0 (0.0) |
a Number in parentheses represents the proportion of each molecular subgroup within a specific WHO grade.
b P-value from the chi-square test to compare WHO grade constituents between the two cohorts.