Fig. 2.

Percent and absolute change in parameter values. From S1 to S2, significant differences between treatment arms were found for percent change for (A) nRCBV (P = 0.03) and (B) sRCBV (P = 0.03) but not (C) K^trans (P = 0.28) and absolute change for (D) nRCBV (P = 0.03) and (E) sRCBV (P = 0.02) but not (F) K^trans (P = 0.23). From S1 to S3, significant differences between treatment arms were found for percent change for nRCBV (P = 0.007), sRCBV (P = 0.01), and K^trans (P = 0.045). The Wilcoxon rank sum test was used for all comparisons.