Table 1. Top-5 genes most consistently overexpressed with age across datasets for all tissues and for each tissue studied.
 |
All Tissues – 449 genes | ||
| Symbol | Gene name | p-value (1.01e-3) | |
| C1QA | Complement C1q A chain | 3.54e-22 | |
| GPNMB | Glycoprotein nmb | 1.64e-21 | |
| B2M | Beta-2-microglobulin | 2.55e-20 | |
| EFEMP1 | EGF containing fibulin extracellular matrix protein 1 | 8.06e-20 | |
| C1QC | Complement C1q C chain | 1.07e-18 | |
| Brain – 147 genes | |||
| Symbol | Gene name | p-value (2.95e-4) | |
| C1QA | Complement C1q A chain | 1.21e-15 | |
| GFAP | Glial fibrillary acidic protein | 1.00e-13 | |
| C1QB | Complement C1q B chain | 7.06e-13 | |
| C1QC | Complement C1q C chain | 2.06e-12 | |
| B2M | Beta-2-microglobulin | 1.19e-11 | |
| Heart – 35 genes | |||
| Symbol | Gene name | p-value (6.43e-4) | |
| MGP | Matrix Gla protein | 5.57e-4 | |
| MAOA | Monoamine oxidase | 5.57e-4 | |
| CP | Ceruloplasmin | 5.57e-4 | |
| VAT1 | Vesicle amine transport 1 | 8.63e-4 | |
| TMED3 | Transmembrane p24 trafficking protein 3 | 8.63e-4 | |
| Muscle – 49 genes | |||
| Symbol | Gene name | p-value (4.89e-4) | |
| CDKN1A | Cyclin dependent kinase inhibitor 1A | 1.84e-8 | |
| RNF115 | Ring finger protein 115 | 7.22e-7 | |
| EFEMP1 | EGF containing fibulin extracellular matrix protein 1 | 7.22e-7 | |
| CHRNA1 | Cholinergic receptor nicotinic alpha 1 subunit | 2.57e-6 | |
| RPS27L | Ribosomal protein S27 like | 4.22e-6 | |
The value given between brackets in the ‘p-value’ column header is the p-value threshold at which FDR <0.05.