Table 4. Summary of results from the GO enrichment and feature importance analyses on the genes overexpressed with age.
 |
All tissues (Overexpressed) | |||
| GO.ID | Term | p-value | Precision (0.0251) | |
| GO:2001198 | Regulation of dendritic cell differentiation | 2.00e-4 | 0.613 | |
| GO:0071276 | Cellular response to cadmium ion | 2.90e-5 | 0.571 | |
| GO:0071294 | Cellular response to zinc ion | 3.00e-6 | 0.452 | |
| GO:0006958 | Complement activation, classical pathway | 1.30e-6 | 0.276 | |
| O:0051043 | Regulation of membrane protein ectodomain proteolysis | 3.30e-4 | 0.267 | |
| Brain (Overexpressed) | ||||
| GO.ID | Term | p-value | Precision (0.0083) | |
| GO:2001198 | Regulation of dendritic cell differentiation | 1.40e-4 | 0.298 | |
| GO:0006958 | Complement activation, classical pathway | 3.30e-7 | 0.135 | |
| GO:0071803 | Positive regulation of podosome assembly | 7.90e-5 | 0.128 | |
| GO:1902106 | Negative regulation of leukocyte differentiation | 2.20e-4 | 0.118 | |
| GO:0032570 | Response to progesterone | 9.30e-4 | 0.109 | |
| Heart (Overexpressed) | ||||
| GO.ID | Term | p-value | Precision (0.0025) | |
| GO:0071295 | Cellular response to vitamin | 2.56e-2 | 0.0761 | |
| GO:0042246 | Tissue regeneration | 5.90e-3 | 0.0462 | |
| GO:0055072 | Iron ion homeostasis | 4.49e-2 | 0.0323 | |
| GO:0007205 | Protein kinase C-activating G protein-coupled receptor signalling pathway | 1.90e-3 | 0.0289 | |
| GO:0018149 | Peptide cross-linking | 5.70e-3 | 0.0285 | |
| Muscle (Overexpressed) | ||||
| GO.ID | Term | p-value | Precision (0.0028) | |
| GO:0031571 | Mitotic G1 DNA damage checkpoint | 2.70e-4 | 0.08 | |
| GO:0032925 | Regulation of activin receptor signalling pathway | 4.21e-2 | 0.0566 | |
| GO:0006195 | Purine nucleotide catabolic process | 6.99e-3 | 0.0279 | |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2.70e-4 | 0.0251 | |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | 5.03e-3 | 0.025 | |
Presented here are a selection of terms for each tissue which were both significantly enriched in the given gene list and present in the top-20 terms, ranked by precision, for the prediction of a gene as being overexpressed by the Random Forest model. The value given between brackets in the Precision column header is the class label’s relative class frequency, i.e. the precision that a classifier would get by randomly classifying the genes.