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. 2021 Jan 20;13(3):3969–3993. doi: 10.18632/aging.202365

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Copyright: © 2021 Yuan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Effect of selected genes on the cytotoxicity of sorafenib. Experimental verification of the relationship between the selected genes and sorafenib resistance in vitro. (A) Transcriptional expression of four selected genes in Huh7 cells compared to LO2. With transfection with siRNA or lncRNA smart silencer, the treated Huh7 cells were exposed to sorafenib, and cell proliferation and invasion were detected 48 hours later. (B, C) The effects of sorafenib on Huh7 proliferation and invasion after RNA interference. **p<0.01, ****p<0.0001.