Table 1. Correlations between TSKU expression and markers of TIICs in the TIMER database.
| Immune cells | Gene markers | LUAD | LUSC | ||||||
| None | Purity | None | Purity | ||||||
| Cor | P | Cor | P | Cor | P | Cor | P | ||
| CD8+ T cell | CD8A | -0.034 | 0.440 | -0.057 | 0.210 | -0.230 | *** | -0.230 | *** |
| CD8B | -0.035 | 0.430 | -0.050 | 0.270 | -0.288 | *** | -0.283 | *** | |
| T cell | CD3D | -0.081 | 0.068 | -0.107 | * | -0.241 | *** | -0.250 | *** |
| (general) | CD3E | -0.111 | * | -0.148 | ** | -0.220 | *** | -0.234 | *** |
| CD2 | -0.116 | * | -0.145 | * | -0.232 | *** | -0.240 | *** | |
| B cell | CD19 | -0.138 | ** | -0.184 | *** | -0.182 | *** | -0.203 | *** |
| CD20 (MS4A1) | -0.177 | *** | -0.216 | *** | -0.223 | *** | -0.250 | *** | |
| CD21 (CR2) | -0.193 | *** | -0.211 | *** | -0.154 | ** | -0.163 | ** | |
| CD40L (CD40LG) | -0.258 | *** | -0.283 | *** | -0.271 | *** | -0.302 | *** | |
| Monocyte | CD86 | -0.081 | 0.066 | -0.094 | * | -0.171 | ** | -0.167 | ** |
| CD115 (CSF1R) | -0.084 | 0.058 | -0.084 | 0.064 | -0.079 | 0.078 | -0.060 | 0.190 | |
| TAM | CCL2 | -0.064 | 0.130 | -0.064 | 0.160 | -0.151 | ** | -0.138 | * |
| CD68 | 0.060 | 0.170 | 0.064 | 0.150 | 0.052 | 0.240 | 0.079 | 0.083 | |
| IL10 | -0.058 | 0.190 | -0.060 | 0.180 | -0.132 | * | -0.120 | * | |
| M1 | INOS (NOS2) | 0.034 | 0.440 | 0.014 | 0.750 | -0.180 | *** | -0.190 | *** |
| Macrophage | IRF5 | 0.032 | 0.470 | 0.039 | 0.390 | 0.116 | * | 0.139 | * |
| COX2 (PTGS2) | -0.091 | * | -0.103 | * | -0.121 | * | -0.123 | * | |
| M2 | CD163 | -0.029 | 0.510 | -0.034 | 0.450 | -0.088 | 0.050 | -0.075 | 0.100 |
| Macrophage | VSIG4 | -0.060 | 0.170 | -0.061 | 0.180 | -0.074 | 0.098 | -0.056 | 0.220 |
| MS4A4A | -0.097 | * | -0.103 | * | -0.105 | * | -0.089 | 0.050 | |
| Neutrophils | CD66b (CEACAM8) | -0.263 | *** | -0.253 | *** | -0.076 | 0.090 | -0.072 | 0.120 |
| CD11b (ITGAM) | -0.128 | * | -0.125 | * | -0.152 | ** | -0.152 | ** | |
| CCR7 | -0.173 | *** | -0.204 | *** | -0.255 | *** | -0.274 | *** | |
| Natural | KIR2DL1 | 0.013 | 0.780 | 0.007 | 0.870 | -0.074 | 0.090 | -0.072 | 0.120 |
| killer | KIR2DL3 | 0.067 | 0.130 | 0.059 | 0.190 | -0.104 | * | -0.100 | * |
| KIR2DL4 | 0.132 | * | 0.114 | * | 0.036 | 0.430 | 0.053 | 0.250 | |
| KIR3DL1 | 0.009 | 0.850 | 0.007 | 0.870 | -0.096 | * | -0.081 | 0.078 | |
| Dendritic | HLA-DPB1 | -0.223 | *** | -0.244 | *** | -0.179 | *** | -0.187 | *** |
| cell | HLA-DQB1 | -0.146 | ** | -0.159 | ** | -0.108 | * | -0.102 | * |
| HLA-DRA | -0.203 | *** | -0.220 | *** | -0.197 | *** | -0.198 | *** | |
| HLA-DPA1 | -0.218 | *** | -0.231 | *** | -0.199 | *** | -0.205 | *** | |
| BDCA-1 (CD1C) | -0.311 | *** | -0.305 | *** | -0.065 | 0.150 | -0.052 | 0.260 | |
| BDCA-4 (NRP1) | -0.178 | *** | -0.175 | *** | 0.077 | 0.084 | 0.107 | * | |
| Th1 | T-bet (TBX21) | -0.042 | 0.340 | -0.062 | 0.170 | -0.235 | *** | -0.245 | *** |
| STAT4 | -0.113 | * | -0.129 | * | -0.209 | *** | -0.219 | *** | |
| STAT1 | 0.131 | * | 0.128 | * | -0.063 | 0.160 | -0.057 | 0.210 | |
| IFN-γ (IFNG) | 0.084 | 0.056 | 0.076 | 0.090 | -0.166 | ** | -0.159 | ** | |
| TNF-α (TNF) | -0.103 | * | -0.101 | * | -0.159 | ** | -0.159 | ** | |
| Th2 | GATA3 | 0.035 | 0.430 | 0.047 | 0.300 | -0.143 | * | -0.150 | ** |
| STAT6 | -0.122 | * | -0.124 | * | -0.084 | 0.062 | -0.095 | * | |
| STAT5A | -0.093 | * | -0.097 | * | -0.185 | *** | -0.186 | *** | |
| IL13 | -0.088 | * | -0.087 | 0.054 | -0.159 | ** | -0.150 | ** | |
| Tfh | BCL6 | -0.176 | *** | -0.171 | ** | 0.106 | * | 0.099 | * |
| IL21 | -0.033 | 0.450 | -0.040 | 0.370 | -0.148 | ** | -0.134 | * | |
| Th17 | STAT3 | -0.075 | 0.095 | -0.075 | 0.098 | 0.007 | 0.880 | 0.007 | 0.880 |
| IL17A | -0.036 | 0.420 | -0.054 | 0.230 | -0.115 | * | -0.115 | * | |
| Treg | FOXP3 | -0.024 | 0.590 | -0.043 | 0.360 | -0.178 | *** | -0.181 | *** |
| CCR8 | -0.116 | * | -0.130 | * | -0.177 | *** | -0.170 | ** | |
| STAT5B | -0.186 | *** | -0.188 | *** | -0.043 | 0.330 | -0.030 | 0.510 | |
| TGFβ (TGFB1) | -0.177 | *** | -0.186 | *** | 0.154 | ** | 0.162 | ** | |
| T cell | PD-1 (PDCD1) | 0.035 | 0.420 | 0.021 | 0.640 | -0.206 | *** | -0.212 | *** |
| exhaustion | CTLA4 | -0.097 | * | -0.122 | * | -0.211 | *** | -0.219 | *** |
| LAG3 | 0.083 | 0.059 | 0.074 | 0.100 | -0.175 | *** | -0.172 | ** | |
| TIM-3 (HAVCR2) | -0.035 | 0.430 | -0.040 | 0.370 | -0.125 | * | -0.110 | * | |
| GZMB | 0.141 | * | 0.132 | * | -0.180 | *** | -0.182 | *** | |
LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor(r), value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by tumor purity. *P < 0.05; **P < 0.001; ***P < 0.0001.