Figure 11.

RRM2 promoted cell proliferation and invasion and regulated cell cycle progression of lung cancer cells. (A) CCK-8 proliferation curve of A549 cells transfected with si-RRM2, O-RRM2, si-NC, and O-Control; (B) Transwell assays were performed to evaluate the role of RRM2 on cell invasion; (C) The cell cycle analyzed of A549 cells by flow cytometry; (D) RRM2-associated signaling pathways were determined by western blot assay. *indicates a p-value < 0.05, and **indicates a p-value < 0.01.