Table 4. Gene sets enriched in the high RRM2 expression phenotype.

Gene set name	SIZE	ES	NES	NOM p-Val	FDR q-Val
KEGG_CELL_CYCLE	124	0.839	2.697	<0.001	<0.001
KEGG_P53_SIGNALING_PATHWAY	66	0.666	2.49	<0.001	<0.001
KEGG_DNA_REPLICATION	36	0.942	2.242	<0.001	1.56e-04
KEGG_SMALL_CELL_LUNG_CANCER	84	0.553	2.077	<0.001	0.003
KEGG_APOPTOSIS	86	0.454	1.758	0.013	0.032
KEGG_PATHWAYS_IN_CANCER	324	0.44	1.863	0.004	0.018

Abbreviations: ES, enrichment score; NES, normalized enrichment score; NOM, nominal; FDR, false discovery rate.

Gene sets with NOM P-value <0.05 and FDR q-value <0.25 were considered as significantly enriched.