Table 2. Univariate cox regression analyses of primary and validation cohorts.

Characteristic	Primary cohorts(n=8658)			Validation cohorts(n=3654)
	HR	95%CI	p value	HR	95%CI	p value
Age			<0.001			<0.001
≤55	Ref			Ref
> 55	1.165	(1.080-1.257)	<0.001	1.398	(1.239-1.576)	<0.001
Race			<0.001			<0.001
White	Ref			Ref
Black	1.154	(1.061-1.255)	0.001	1.147	(1.012-1.300)	0.031
Other	0.818	(0.755-0.886)	<0.001	0.788	(0.699-0.889)	<0.001
Sex			0.001			0.047
Male	Ref			Ref
Female	0.898	(0.842- 0.958)	0.001	0.903	(0.817-0.998)	0.047
Grade			<0.001			<0.001
1	Ref			Ref
2	1.039	(0.969-1.115)	0.284	0.995	(0.894-1.107)	0.923
3	1.932	(1.789-2.087)	<0.001	1.644	(1.459-1.852)	<0.001
4	2.169	(1.764-2.666)	<0.001	2.115	(1.521-2.940)	<0.001
Tumor T			<0.001			<0.001
TX	Ref			Ref
T0	1.537	(0.680-3.474)	0.301	0.936	(0.295-2.970)	0.910
T1	0.298	(0.253-0.351)	<0.001	0.312	(0.246-0.397)	<0.001
T2	0.354	(0.299-0.419)	<0.001	0.359	(0.280-0.459)	<0.001
T3	0.877	(0.744-1.033)	0.116	0.875	(0.688-1.113)	0.277
T4	0.861	(0.708-1.049)	0.137	0.929	(0.695-1.243)	0.620
Tumor N			<0.001			<0.001
N0	Ref			Ref
N1	2.577	(2.360-2.813)	<0.001	2.412	(2.102-2.769)	<0.001
NX	2.273	(2.025-2.553)	<0.001	2.564	(2.175-3.022)	<0.001
Tumor M			<0.001			<0.001
M0	Ref			Ref
M1	3.527	(3.270-3.804)	<0.001	3.219	(2.866-3.616)	<0.001
Marital status			<0.001			<0.001
Divorced	Ref			Ref
Single	1.051	(0.946-1.169)	0.354	0.986	(0.844-1.152)	0.863
Married	0.855	(0.780-0.938)	0.001	0.795	(0.694-0.911)	0.001
Separated	1.141	(0.905-1.437)	0.264	1.237	(0.869-1.762)	0.238
Windowed	1.222	(1.087-1.374)	0.001	0.990	(0.828-1.183)	0.911
Unmarried or Domestic partner	0.515	(0.256-1.036)	0.063	0.622	(0.277-1.398)	0.251
Tumor size(mm)			<0.001			<0.001
≤30	Ref			Ref
>30	2.382	(2.208-2.569)	<0.001	2.265	(2.020-2.541)	<0.001
Histologic Type			0.009			0.280
ICCs	Ref			Ref
HCC	0.872	(0.798-0.952)	0.002	0.895	(0.776-1.033)	0.129
Combined	0.797	(0.378-1.679)	0.550	0.708	(0.263-1.903)	0.493