Table 3. Multivariate cox regression analyses of primary and validation cohorts.

Characteristic	Primary cohort(n=8658)			Validation cohort(n=3654)
	HR	95%CI	p value	HR	95%CI	p value
Age			<0.001			<0.001
≤55	Ref			Ref
> 55	1.198	(1.109-1.295)	<0.001	1.442	(1.275-1.630)	<0.001
Race			<0.001			0.033
White	Ref			Ref
Black	1.084	(0.994-1.182)	0.068	1.056	(0.929-1.200)	0.404
Other	0.805	(0.742-0.873)	<0.001	0.863	(0.763-0.977)	0.020
Sex			<0.001			0.012
Male	Ref			Ref
Female	0.868	(0.810-0.930)	<0.001	0.873	(0.784-0.971)	0.012
Grade			<0.001			<0.001
1	Ref			Ref
2	0.980	(0.913-1.053)	0.586	0.974	(0.874-1.085)	0.627
3	1.578	(1.456-1.710)	<0.001	1.442	(1.276-1.631)	<0.001
4	1.615	(1.311-1.990)	<0.001	1.856	(1.327-2.595)	<0.001
Tumor T			<0.001			<0.001
TX	Ref			Ref
T0	1.722	(0.754-3.932)	0.197	1.074	(0.332-3.477)	0.905
T1	0.489	(0.410-0.582)	<0.001	0.499	(0.385-0.645)	<0.001
T2	0.554	(0.463-0.663)	<0.001	0.564	(0.433-0.734)	<0.001
T3	1.014	(0.853-1.206)	0.874	1.026	(0.794-1.325)	0.846
T4	0.907	(0.739-1.113)	0.349	1.026	(0.756-1.392)	0.871
Tumor N			<0.001			<0.001
N0	Ref			Ref
N1	1.447	(1.311-1.597)	<0.001	1.529	(1.312-1.783)	<0.001
NX	1.431	(1.264-1.621)	<0.001	1.790	(1.500-2.136)	<0.001
Tumor M			<0.001			<0.001
M0	Ref			Ref
M1	2.190	(2.013-2.383)	<0.001	2.038	(1.793-2.317)	<0.001
Marital status			<0.001			<0.001
Divorced	Ref			Ref
Single	1.060	(0.952-1.198)	0.288	1.016	(0.868-1.189)	0.845
Married	0.805	(0.805-0.953)	0.011	0.797	(0.694-0.915)	0.001
Separated	1.221	(0.969-1.540)	0.091	1.411	(0.990-2.011)	0.057
Windowed	1.251	(1.029-1.410)	<0.001	1.042	(0.867-1.252)	0.659
Unmarried or Domestic partner	0.547	(0.272-1.101)	0.091	0.572	(0.253-1.286)	0.177
Tumor size			<0.001			<0.001
≤30	Ref			Ref
>30	1.752	(1.617-1.899)	<0.001	1.657	(1.466-1.873)	<0.001
Histologic Type			0.005			0.038
ICCs	Ref			Ref
HCC	1.168	(1.060-1.287)	0.002	1.2220	(1.042-1.429)	0.013
Combined	0.802	(0.380-1.692)	0.563	0.862	(0.318-2.335)	0.771