Table 2.
Summary of clinical, subjective, and quantitative features from prototype in patients with best predictive area under the curve for differentiating those with and without ICU admission and those with recovery versus death from COVID-19 pneumonia. All AUCs were statistically significant (p = 0.04–< 0.0001)
| Site A | Site B | ||||||
|---|---|---|---|---|---|---|---|
| Features | Best subset | AUC | 95% CI | Best subset | AUC | 95% CI | |
| With vs. without ICU admission | Radiologists | Subjective severity score | 0.77 | 0.77–0.81 | Subjective severity score | 0.69 | 0.69–0.74 |
| AI | Volume of opacity + percentage of high opacity | 0.82 | 0.79–0.82 | Opacity score + percentage of high opacity | 0.76 | 0.73–0.79 | |
| Clinical | WBC count | 0.64 | 0.64–0.69 | Patient age | 0.68 | 0.68 | |
| Clinical + radiologists | Subjective severity score | 0.77 | 0.77–0.81 | Subjective severity score + patient age | 0.76 | 0.7–0.77 | |
| Clinical + AI | Volume of opacity + percentage of high opacity | 0.82 | 0.79–0.82 | Opacity score + percentage of high opacity + patient age | 0.8 | 0.73–0.83 | |
| Recovered vs. deceased | Radiologists | Subjective severity score | 0.68 | 0.67–0.68 | Subjective severity score | 0.68 | 0.67–0.68 |
| AI | Volume of opacity | 0.72 | 0.7–0.72 | Percentage of high opacity + volume of opacity | 0.77 | 0.7–0.84 | |
| Clinical | LDH | 0.69 | 0.69 | No features selected | -* | - | |
| Clinical + radiologists | Subjective severity score + LDH | 0.72 | 0.69–0.73 | Subjective severity score + patient age | 0.76 | 0.68–0.8 | |
| Clinical + AI | Volume of opacity + LDH | 0.74 | 0.71–0.77 | Percentage of high opacity + patient age | 0.8 | 0.69–0.87 | |
*p-value > 0.06 (AUC 0.71)