Figure 1.

Antibody conjugates constructed via a convergent assembly [1]. (a) Site-specific, transglutaminase (TGase)-catalyzed conjugation leads to homogenous constructs that preserve binding affinity. (b) Non-specific chemical modification, such as acylation of amines, yields a heterogenous mixture that ultimately reduces binding affinity. Adapted with permission from Sadiki et al. [1]. Copyright © 2020, John Wiley, and Sons.