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. 2021 Feb 25;17(2):e1009248. doi: 10.1371/journal.ppat.1009248

Fig 1. Surface recruitment of human proteins by Strep A.

Fig 1

Left, Schematic of the M protein coiled coil attached covalently to the Strep A cell wall. The N-terminal 50 amino acids of mature M protein define its type (cyan), and the N-terminal third to half of M protein is sequence variable (orange). Right, M and M-like proteins on the Strep A surface recruit C4BP, FH, Fg, and Pla to block the deposition of opsonins, such as C3b and antigen-specific antibodies. M and M-like proteins also interact with IgG and IgA in nonimmune fashion through their Fc domains. C4BP, C4b-binding protein; Fc, fragment crystallizable; Fg, fibrinogen; FH, factor H; IgA, immunoglobulin A; IgG, immunoglobulin G; Pla, plasminogen.