Table 1. Distribution of studies on the effects of therapeutic hypothermia on death among asphyxiated neonates with hypoxic-ischemic encephalopathy.
| Authors | Year | Country | Income | N Hypo: STD | Cooling method/Device | Mortality HYPO:STD | Relative risk | Yes Total | Overall appraisal |
|---|---|---|---|---|---|---|---|---|---|
| Lin et al. [28] | 2006 | China | upper-middle | 32:30 | SHC: cooling caps | 2:2 | 0.94 | 12/13 | Included |
| Zhou et al. [29] | 2010 | China | upper-middle | 138:118 | SHC: cooling caps | 31:46 | 0.85 | 13/13 | Included |
| Akisu et al. [20] | 2013 | Turkey | upper-middle | 11:10 | SHC: cooling caps | 0:2 | 0 | 13/13 | Included |
| Robertson et al. [30] | 2008 | Uganda | Low | 21:15 | WBC: cooling blanket | 1:7 | 0.1 | 11/13 | Included |
| Thayyil et al. [31] | 2013 | India | low-middle | 17:16 | WBC: cooling blanket | 4:2 | 3.2 | 12/13 | Included |
| Bharadwaj et al. [32] | 2012 | India | low-middle | 62:62 | WHC: cold gel pack | 3:6 | 0.5 | 11/13 | Included |
| Bhat et al. [33] | 2006 | India | low-middle | 20:15 | WHC: cold gel pack | 3:5 | 0.45 | 13/13 | Included |
| Azzoparadi et al. [21] | 2009 | UK | High | 163:162 | WHC: cooling blanket | 42:44 | 0.86 | 12/13 | Included |
| Jacobs et al. [34] | 2011 | Australia | High | 91:78 | WHC: cold gel pack | 51:58 | 0.75 | 12/13 | Included |
| Shankaran et al. [35] | 2005 | USA | High | 102:103 | WHC: cooling blanket | 45:64 | 0.71 | 12/13 | Included |
| Simbruner et al. [36] | 2010 | Germany | High | 53:58 | WHC: cooling blanket | 27:48 | 0.62 | 11/13 | Included |
| Gluckman et al. [37] | 2005 | USA | High | 108:110 | SHC: cooling caps | 36:42 | 0.82 | 13/13 | Included |
| Zhou et al. [29] | 2010 | China | upper-middle | 100:94 | SHC: cooling caps | 31:46 | 0.65 | 12/13 | Included |
| Eicher et al. [38] | 2005 | USA | High | 32:33 | WHC: cooling blanket | 10:14 | 0.75 | 13/13 | Included |
| Battin et al. [39] | 2003 | New Zealand | High | 13:13 | SHC: cooling caps | 5:7 | 0.72 | 12/13 | Included |
| Shankaran et al. [40] | 2002 | USA | High | 9:10 | WHC: cooling blanket | 2:3 | 0.74 | 13/13 | Included |
| Joy et al. [41] | 2012 | India | low-middle | 58:58 | WHC: cold gel pack | 1:4 | 0.25 | 11/13 | Included |
| Maoulainine et al. [42] | 2017 | Morocco | Low | 19:19 | SHC; cooling caps | 3:7 | 0.43 | 13/13 | Included |
| Laptook et al. [43] | 2018 | USA | High | 83:85 | WBC: cooling blanket | 6:5 | 0.86 | 12/13 | Included |
| Gane et al. [44] | 2013 | India | low-middle | 53:50 | WBC: cold gel pack | 4:8 | 0.5 | 13/13 | Included |
| Selway et al [45] | 2010 | USA | High | 102:103 | WBC: cold gel pack | 24:38 | 0.65 | 12/13 | Included |
| Susan et al. [34] | 2011 | USA | High | 110:111 | WBC: cold gel pack | 55:67 | 0.77 | 13/13 | Included |
| Jose et al. [46] | 2018 | India | low-middle | 74:70 | WBC: cold gel pack | 18:28 | 0.6 | 12/13 | Included |
| Azzopardi et al. [47] | 2014 | UK | High | 145:135 | WHC: cooling blanket | 47:49 | 0.95 | 10/13 | Included |
| Shankaran et al. [48] | 2012 | USA | High | 58:43 | WBC: cold gel pack | 6:7 | 0.64 | 10/13 | Included |
| Battin et al. [49] | 2001 | New Zealand | High | 20:20 | SHC: cooling caps | 3:4 | 0.75 | 11/13 | Included |
| Gane et al. [44] | 2013 | India | low-middle | 60:60 | WBC: cold gel pack | 4:8 | 0.5 | 10/13 | Included |
| Namasivayam et al. [43] | 2017 | USA | High | 78:79 | WBC: cold gel pack | 19:22 | 0.85 | 11/13 | Included |