Fig 2.

Gene expression prediction models of hippocampal tissue (A) and TWAS results of AD (B). (A) Average Pearson correlation coefficients of 15,017 significant hippocampal gene expression prediction models (p_c < 0.05, FWE corrected). (B) Manhattan plot of all TWAS associations of AD in the discovery stage. Each point represents a single gene, with physical position in chromosome plotted on the x-axis and z-score of the association statistics between gene and AD plotted on the y-axis. Transcriptome-wide significant threshold (q_c < 0.05, FDR corrected) is highlighted as black dotted lines and the significant associations are labeled with gene names. AD, Alzheimer’s disease; FDR, false discovery rate; FWE, familywise error; TWAS, transcriptome-wide association study.