Table 2. Seven TWAS significant genes were validated in the ADNI neuroimaging data.

Gene	AD TWAS		ADNI validation
	TWAS_Z	TWAS_P	OR	95%CI	SE	P
QPCTL	-23.332	2.10 × 10−120	0.760	0.656 to 0.882	0.076	2.89 × 10−4
DMPK	-22.672	8.54 × 10−114	0.774	0.666 to 0.900	0.077	8.77 × 10−4
ERCC2	17.870	2.01× 10−71	1.199	1.040 to 1.382	0.073	1.25 × 10−2
CD3EAP	14.916	2.60× 10−50	1.396	1.199 to 1.625	0.078	1.70 × 10−5
APOE	-12.901	4.43× 10−38	0.814	0.707 to 0.938	0.072	4.37 × 10−3
PPP1R37	-6.710	1.95× 10−11	0.834	0.722 to 0.964	0.074	1.41 × 10−2
PVRL2	4.458	8.26× 10−6	1.166	1.010 to 1.346	0.073	3.65 × 10−2

OR-values, 95% CI, SE-values and P-values are from binary logistic regression.

AD = Alzheimer’s disease, ADNI = Alzheimer’s Disease Neuroimaging Initiative

TWAS = transcriptome-wide association study, OR = odds ratio, CI = confidence interval, SE = standard error.

The abbreviation of genes is referred to at https://www.ncbi.nlm.nih.gov/gen.