Table 3. Comparison of RNFL and macular thicknesses among patients with metabolic syndrome at different tertile levels of metabolic components.
| Variables | Global RNFL (um) | Superior RNFL (um) | Global Parafoveal (um) | Inferior Parafoveal (um) | Global Perifoveal(um) | Central macula (um) |
|---|---|---|---|---|---|---|
| HbA1c 1st tertile (n = 51) | 95.12 ± 8.45 | 117.80 ± 15.49 | 316.88 ± 13.71 | 315.57 ± 15.91 | 272.42 ± 39.50 | 236.27 ± 14.04 |
| 2nd tertile (n = 29) | 95.03 ± 9.34 | 119.80 ±16.24 | 308.50 ± 19.98 | 298.96 ± 24.27 | 279.27 ± 16.49 | 238.38 ± 14.23 |
| 3rd tertile (n = 33) | 93.03 ± 11.58 | 113.97 ±16.68 | 305.93 ± 18.72 | 303.61 ± 20.71 | 272.51 ± 12.12 | 236.76 ± 14.10 |
| P value * | 0.05 | 0.34 | 0.013 |
0.0008. ⸹ p = 0.001 ¶ p = 0.023 |
0.54 | 0.81 |
| FBS 1st tertile (n = 41) | 92.68 ± 8.66 | 113.51 ±15.31 | 310.69 ± 17.43 | 305.90 ± 17.89 | 278.34 ± 13.60 | 234.29 ± 12.49 |
| 2nd tertile (n = 40) | 95.67 ± 9.17 | 120.72 ±15.34 | 317.36 ± 14.34 | 314.32 ± 21.72 | 271.43 ± 44.71 | 239.17 ± 14.13 |
| 3rd tertile (n = 32) | 92.22 ± 11.85 | 117.5 ±17.25 | 305.32 ± 19.50 | 302.12 ± 21.80 | 272.37 ± 12.48 | 237.59 ± 15.48 |
| P value * | 0.25 | 0.13 | 0.013 | 0.035 | 0.51 | 0.28 |
| SBP 1st tertile (n = 40) | 93.7 ± 9.68 | 116.92 ± 15.84 | 312.92 ± 18.99 | 308.95 ± 21.77 | 277.08± 14.21 | 236.22 ± 15.49 |
| 2nd tertile (n = 42) | 91.98 ± 10.05 | 115.79 ± 15.80 | 307.30 ± 18.40 | 305.17 ± 19.98 | 266.06 ± 43.30 | 239.31 ± 12.05 |
| 3rd tertile (n = 31) | 95.71 ± 9.76 | 119.45 ± 16.90 | 315.5 ± 13.30 | 309.93 ± 21.19 | 281.5 ± 7.69 | 234.71 ± 14.43 |
| P value * | 0.28 | 0.62 | 0.11 | 0.57 | 0.05 | 0.35 |
| DBP 1st tertile (n = 45) | 90.24 ± 10.26 | 110.89 ± 15.53 | 314.05 ± 20.64 | 308.73 ± 24.91 | 270.05 ± 43.68 | 238.27 ± 14.39 |
| 2nd tertile (n = 35) | 94.97 ± 8.15 | 120.17 ± 11.51 | 307.85 ± 15.73 | 305.77 ± 16.94 | 274.06 ± 10.47 | 239.51 ± 12.48 |
| 3rd tertile (n = 33) | 96.76 ± 9.85 | 122.64 ± 18.24 | 312 ± 15.46 | 308.72 ± 18.99 | 280.03 ± 7.4 | 232.45 ± 14.35 |
| P value * | 0.009 |
0.002 ⸹ p = 0.025 ¶ p = 0.003 |
0.29 | 0.79 | 0.31 | 0.08 |
| HDL 1st tertile (n = 45) | 94.84 ± 10.41 | 119.89 ± 16.50 | 309.59 ± 17.09 | 306.89 ± 19.7 | 273.9 ± 9.52 | 237.31 ±12.3 |
| 2nd tertile (n = 40) | 91.8 ± 9.27 | 114.0 ± 15.55 | 309.45 ± 18.10 | 302.2 ± 22.55 | 278.62 ± 15.12 | 236.75 ± 14.5 |
| 3rd tertile (n = 28) | 94.21 ± 9.76 | 117.43 ± 15.75 | 317.62 ± 16.70 | 317.32 ± 17.29 | 268.4 ± 53.29 | 236.68 ± 15.55 |
| P value* | 0.34 | 0.24 | 0.10 | 0.011 | 0.34 | 0.97 |
| Triglycerides 1st tertile (n = 37) | 94.54 ± 11.02 | 116.73 ± 15.61 | 310.38 ± 16.56 | 309.84 ±17.38 | 275.62 ± 10.95 | 235.48 ± 12.90 |
| 2nd tertile (n = 44) | 92.36 ± 9.76 | 116.34 ± 17.62 | 312.24 ± 18.56 | 309.54 ±22.09 | 270.50 ± 42.58 | 239.52 ± 15.37 |
| 3rd tertile (n = 32) | 94.25 ± 8.65 | 118.91 ± 14.45 | 311.88 ± 17.77 | 303.09 ± 22.68 | 277.67 ± 16.05 | 235.12 ± 13.15 |
| P-value* | 0.56 | 0.77 | 0.88 | 0.32 | 0.52 | 0.29 |
| Overweight (BMI<30) | 92 ± 11.30 | 115.71 ± 16.22 | 316.56 ± 14.46 | 312.33 ± 21.22 | 364.08 ± 56.66 | 239.5 ± 11.68 |
| Obese (BMI ≥30) | 94.04 ± 9.46 | 117.59 ± 16.07 | 310.18 ± 18.14 | 306.59 ±20.73 | 276.94 ± 12.76 | 236.27 ± 14.55 |
| P-value* | 0.36 | 0.6 | 0.11 | 0.23 | 0.05 | 0.31 |
| 3 Components | 96.71 ± 8.70 | 119.32 ± 16.6 | 315.25 ± 17.08 | 310.91 ± 20.63 | 274.39 ±039.02 | 235.68 ± 14.28 |
| 4 Components | 91.0 ± 7.01 | 114.18 ± 11.11 | 312.63 ± 17.20 | 309.36 ± 20.09 | 276.70 ± 11.17 | 242.14 ± 13.10 |
| 5 Components | 90.14 ± 12.44 | 116 ± 18.7 | 303.28 ± 16.62 | 300.34 ± 19.97 | 271.44 ± 11.68 | 234.41 ± 13.50 |
| P-value* |
0.0032 ⸹ p = 0.031 ¶ p = 0.009 |
0.34 | 0.0099 | 0.771 | 0.78 | 0.007 |
* = one-way ANOVA. P<0.004 is considered statistically significant to correct for multiple comparison.
⸹ = Bonferroni correction for ANOVA between 1st and 2nd tertile.
¶ = Bonferroni correction for ANOVA between 2nd and 3rd tertile. RNFL = retinal nerve fiber layer. All values are presented as mean ± standard deviation. Obesity was not included in the table as there was no thickness difference in any of the retinal sectors with obesity.