Table 1.
Secreted effectors and OMPs of H. pylori that we analyzed with our interface-based computational approach
| H. pylori protein | PDB | OMP or secreted effector | Known targets in human | Complex structures for the known HPIs in PDB | Number of HPIs modeled |
|---|---|---|---|---|---|
| CagA (HP0547) | 4dvyP | Secreted | TP53B2 [58] MARK2 (PAR1B) [59] CRK [60] E-Cadherin (CADH1) [61,62] MET (HGFR) [61] ZO1 [63] JAM1 [63] PLCγ [64] GRB2 [65] CSK [66] SHP-2 (PTN11) [5,67] SHP-1 (PTN6) [68] PI3K (P85A) [68] GRB7 [68] RASA1 (Ras-GAP1) [68] TAK1 [69] |
4irv:AE 3iec:AE |
69 |
| VacA | 2qv3A | Secreted | LFA1 (ITGAL) [70] CD18 (ITGB2) [71] RPTP-α [72] RPTP-β [72] LRP1 [73] Fibronectin [74] |
15 | |
| BabA (HP1243) | 4zh0A | OMP | Lewis(b) antigen [75] MUC5B [76] |
16 | |
| SabA (HP0725) | 4o5jA | OMP | Lewis(x) [77] MUC5B [76] |
18 | |
| gGT (HP1118) | 2nqoA 2nqoB |
Secreted | No known HPIs | 25 | |
| Cagα (HP0525) | 2pt7A | OMP | No known HPIs | 26 | |
| HP1286 | 3hpeA | Secreted | No known HPIs | 12 | |
| HP0231 | 3tdgA | Secreted | No known HPIs | 28 | |
| HP0721 | 2xrhA | Secreted | No known HPIs | 9 | |
| HP0827 | 2ki2A | Secreted | No known HPIs | 6 |