Table 5. Ablation study of TranSynergy models.

Drug features	Cell line features	MSE	Spearman Correlation	Pearson Correlation
Network propagated drug target profile	Gene dependency	232 ± 21	0.725±0.016	0.746±0.017
	Gene expression	241 ± 19	0.721±0.021	0.741±0.025
	Gene dependencies + Gene expression	231 ± 21	0.730±0.016	0.746±0.018
	None	390 ± 11	0.505±0.007	0.400±0.012
Observed drug target profile	Gene dependency	305 ± 34	0.634±0.035	0.635±0.048
	Gene expression	307 ± 33	0.634±0.038	0.632±0.039
	Gene dependencies + Gene expression	300 ± 31	0.645±0.036	0.634±0.038