Table 3.
Fold increase data of PATRR DNA compared to backgrounds 9q34 and 10q26.1 for lymphoblastoid cells
| 9q34 | 10q26.1 | |||||
|---|---|---|---|---|---|---|
| γH2AX | Rad51 | NBS1 | γH2AX | Rad51 | NBS1 | |
| PATRR17 | 1.29 | 1.63 | 1.56 | 1.30 | 1.36 | 1.39 |
| PATRR8 | 1.17 | 1.25 | 1.35 | 0.96 | 1.37 | 1.17 |
| PATRR11 | 1.19 | 1.40 | 1.52 | 1.30 | 1.12 | 1.05 |
| PATRR22 | 1.51 | 1.55 | 1.65 | 1.21 | 1.52 | 1.34 |
| PATRR Median | 1.26 | 1.39 | 1.48 | 1.08 | 1.37 | 1.17 |
| PATRR Mean | 1.42 | 1.68 | 1.52 | 1.29 | 1.55 | 1.21 |
| P-value | 0.0016 | 0.0001 | 0.0001 | 0.011 | 0.0001 | 0.0002 |
Data from ChIP assays using DSB-associated antibodies γH2AX, Rad51 and NBS1. Median values are reported for individual PATRRs. Data from all four PATRRs are combined to generate the total PATRR median and mean values for a given antibody. P-values are calculated for the total PATRR value for each antibody using the one-sample t-test comparing the total PATRR to the mean value of 1 using GraphPad Software at www.graphpad.com.