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. 2020 Dec 31;29(24):3900–3918. doi: 10.1093/hmg/ddaa279

Figure 3.

Figure 3

Abundant alternative splicing changes in C9-BAC mice. (A) Venn diagram showing number of alternative splicing changes in Acute and presymptomatic mice compared to NT mice. (B) Alternative splicing events found in both presymptomatic and Acute animals show delta psi values for a group of markers increase with disease severity. (C) Elavl2 is alternatively spliced in both the C9(+) presymptomatic [C9(+)] and Acute mice. (D) Gene IDs and corresponding Δpsi values in C9(+) presymptomatic and Acute animals. Additional information on alternative splicing events is provided in Table 2. (E) Gene Ontology categories are shown for alternatively spliced events found only in C9(+) presymptomatic mice, both presymptomatic and Acute animals (intersection), only Acute animals and C9-ALS patients. (F) Motif analysis of significant alternative splicing changes in C9(+) presymptomatic mice, acute mice and C9-ALS patients shows no enrichment of single motif or unique signature of sequestration of single RNA-binding protein.