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. 2020 Dec 31;29(24):3900–3918. doi: 10.1093/hmg/ddaa279

Figure 5.

Figure 5

Molecular features of C9orf72 ALS/FTD in C9-BAC mice increase with repeat length. (A, B) Quantification of fluorescence in situ hybridization (FISH) detection of sense (A) and antisense (B) RNA foci in the dentate gyrus of the hippocampus. (C) Immunofluorescence (IF) showing representative images of GA and GP RAN protein aggregates in the retrosplenial cortex of 40-week-old female NT, C9–50, C9–500 and C9–800 mice. Scale bar corresponds to 20 μm. (D) Quantification of GA and GP RAN protein aggregates was done in a blinded fashion and is shown as the percentage of neurons with aggregates in NT, C9–50, C9–500 and C9–800 mouse cohorts. Data information: Statistical analyses for (A), (B) and (D) done using a one-way ANOVA with Bonferroni correction for multiple comparisons. Mean +/− SEM, *P < 0.05, **P < 0.01, ****P < 0.0001.