Table 1.
Duffy-null genotype and absolute neutrophil count
| A | CC genotype | TC/TT genotype | ||
|---|---|---|---|---|
| Black African/Caribbean | Other ethnicity | Black African/Caribbean | Other ethnicity | |
| Total N with ANC data | 6002 | 964 | 1220 | 458 077 |
| Mean ANC [SD] | 2.82 [1.02] | 2.79 [1.05] | 4.43 [1.41] | 4.22 [1.34] |
| ANC > 7.5 | 13 (0.22%) | 1 (0.10%) | 32 (2.62%) | 10 774 (2.35%) |
| ANC 2.0–7.5 | 4751 (79.16%) | 735 (76.24%) | 1173 (96.15%) | 440 012 (96.06%) |
| ANC 1.5–2.0 | 935 (15.58%) | 172 (17.84%) | 12 (0.98%) | 5599 (1.22%) |
| ANC 1.0–1.5 | 272 (4.53%) | 48 (4.98%) | 1 (0.08%) | 981 (0.21%) |
| ANC 0.5–1.0 | 28 (0.47%) | 7 (0.73%) | 1 (0.08%) | 380 (0.08%) |
| ANC < 0.5 | 3 (0.05%) | 1 (0.10%) | 1 (0.08%) | 331 (0.07%) |
| B | ||||
| Black African/Caribbean ethnicity | ||||
| CC (n = 6002) | TC/TT (n = 1220) | Odds ratio (95% CI) | P | |
| ANC < 2.0 | 1238 (20.63%) | 15 (1.23%) | 25.46 (14.39–45.06) | 1.06 × 10−28 |
| ANC < 1.5 | 303 (5.05%) | 3 (0.25%) | 45.88 (12.09–174.07) | 1.86 × 10−8 |
| All ethnicities combined | ||||
| CC (n = 6966) | TC/TT (n = 459 297) | Odds ratio (95% CI) | P | |
| ANC < 2.0 | 1466 (21.05%) | 7306 (1.59%) | 32.44 (22.86–46.04) | 1.37 × 10−84 |
| ANC < 1.5 | 359 (5.15%) | 1695 (0.37%) | 45.22 (23.31–87.73) | 1.78 × 10−29 |
Association between the Duffy-null genotype and absolute neutrophil count (ANC) in UK Biobank participants. A provides comparative proportions of individuals with the CC and TC/TT genotypes that fall below certain ANC thresholds. Columns represent ANC thresholds, values for individuals with the CC (Duffy-null) and TT/TC genotypes, respectively, for rs2814778 with (i) a self-reported Black African/Caribbean ethnicity, and (ii) self-reported ‘other’ (non-Black African/Caribbean) ethnicity. B details the association between the CC (Duffy-null) genotype and an ANC < 2.0 × 109/L and 1.5 × 109/L. CI, confidence interval.