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. 2020 Oct 19;29(20):3388–3401. doi: 10.1093/hmg/ddaa224

Figure 2.

Figure 2

Mpp5 heterozygous CKO mice are smaller and have a reduced number of neurons. (A–C) At P21, body length and brain size were measured in Mpp5 het CKO mice and WT littermate controls (B, −17%, P = 0.012). (D–F) Histology with hematoxylin and eosin shows two microcephaly phenotypes—with and without ventriculomegaly. (G, H) Histology of cerebellum of WT and Mpp5 het CKO comparing size and lobe formation at P21. Arrows indicate the absence of molecular layer in the lobe X in Mpp5 het CKO. (I) Cortical thickness of Mpp5 het CKO compared with that of WT (−47%, P = 0.000002). (J) Comparison of cerebellar area between Mpp5 het CKO and WT (−42%, P = 0.0001). Data are presented as mean ± SEM. WT, n = 5; Mpp5 het CKO, n = 5.