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Mpp5 heterozygous CKO mice have a reduced number of neurons. (A–C) Immunostaining of cortical layer-specific neurons (Cux1+, layers 2–4, A; CTIP2+, layer 5, B; FoxP2+, layer 6, C) is shown in Mpp5 het CKO and WT control at P21 (D). The number of layer-specific neurons is compared between Mpp5 het CKO and WT (Cux1+ neurons, −61%, P = 0.0001; CTIP2 + neurons, −42%, P = 0.0001; FoxP2+ neurons, −49%, P = 0.0002). Data are presented as mean ± SEM. WT, n = 5; Mpp5 het CKO, n = 5.
