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. 2020 Oct 12;31(2):1090–1105. doi: 10.1093/cercor/bhaa277

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Intracerebroventricular (i.c.v.) infusions of 5,7-DHT caused profound reductions in 5-HT throughout the brain in Expt. 1 (preacquisition cohort) and Expt. 2 (postacquisition cohort). (a, b) The loss of 5-HT was on average more than 80% in cortical and subcortical areas in both the preacquisition (a) and postacquisition (b) cohorts. (c, d) There were no indications of noradrenaline depletion in either the preacquisition (c) or the postacquisition (d) cohort; instead, there was evidence of an upregulated noradrenaline system in the postacquisition groups. mPFC, medial prefrontal cortex; OFC, orbitofrontal cortex; NAC, nucleus accumbens; Amy, amygdala; DH, dorsal hippocampus. ^*P < 0.05; ^*^*P < 0.01; Student’s t-test, one-tailed to detect 5-HT depletion and two-tailed to test for effects on noradrenaline.