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. 2020 Oct 12;31(2):1090–1105. doi: 10.1093/cercor/bhaa277

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Serotonin (5-HT) levels recovered 3 months after 5,7-DHT infusions in the behavioral cohort (Expt. 3), but remained depleted 3 weeks after 5,7-DHT infusions in a control group (Expt. 4). 5-HT levels had partly and fully recovered in the behavioral cohorts approximately 3 months after mPFC (a) and OFC treatment (e), respectively. Three weeks after local 5,7-DHT infusions in the neurochemistry cohort, 5-HT levels were depleted by 90% in the mPFC (b) and 80% in the OFC (f), respectively. After OFC 5,7-DHT infusions, 5-HT levels in the mPFC were increased (b). No effect of 5,7-DHT treatment on either (c, g) noradrenaline or (d, h) dopamine in the mPFC or OFC in the neurochemistry cohort. ^*P < 0.05 versus Sham; ^*^*^*P < 0.001 versus Sham; one-tailed pairwise comparisons were used to detect 5-HT depletion in the target areas and two-tailed tests for all other comparisons.