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. 2020 Oct 12;31(2):1090–1105. doi: 10.1093/cercor/bhaa277

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of mPFC and OFC 5,7-DHT infusions on visual discrimination and reversal learning (Expt. 3). (a) 5-HT depletion of the mPFC impaired visual discrimination learning versus 5-HT depletion of the OFC, whereas the number of sessions needed to reach criterion in the reversal-learning stage was not significantly increased after OFC 5-HT depletion. (b) Trials committed before reaching criterion was increased during the visual discrimination stage after mPFC 5,7-DHT infusions (vs. OFC rats), whereas 5,7-DHT infusions into the OFC increased the trials to criterion during the reversal stages (vs. both sham controls and mPFC rats). Similar effects were noted on (c) total errors to criterion, (d) errors on standard trials, and (e) errors on correction trials. ^*P < 0.05; ^*^*P < 0.01; Fisher’s LSD post hoc comparison after significant group × stage interaction and significant one-way ANOVA for the relevant stage.