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. Author manuscript; available in PMC: 2021 Feb 25.
Published in final edited form as: Nat Genet. 2020 Mar 30;52(4):437–447. doi: 10.1038/s41588-020-0594-5

Extended Data Fig. 5 ∣. GWAS hits from 23andMe are not specific to MDD.

Extended Data Fig. 5 ∣

This figure shows the odds ratios of risk alleles (Risk Allele ORs) at 17 loci significantly associated with help-seeking based definitions of MDD in 23andMe27, in GWAS conducted on CIDI-based (LifetimeMDD, in purple), help-seeking (GPpsy in red) and no-MDD (GPNoDep, in orange) based definitions of MDD, as well as conditions other than MDD: neuroticism, smoking and SCZ (all in brown). SNPs missing in each panel are not tested in the respective GWAS. For clarity of display, scales on different panels vary to accommodate the different magnitudes of ORs of SNPs in different conditions. ORs at all 17 loci are highly consistent across phenotypes, regardless of whether it is a definition or MDD or a risk factor or condition other than MDD. All results are shown in Supplementary Table 20. Error bars show the standard errors of the estimates.