Skip to main content
. Author manuscript; available in PMC: 2021 Feb 25.
Published in final edited form as: Nat Genet. 2020 Mar 30;52(4):437–447. doi: 10.1038/s41588-020-0594-5

Fig. 5 ∣. Tissue-specific gene expression enrichment in definitions of MDD.

Fig. 5 ∣

The −log10 P value is shown for enrichment in h2SNP in genes specifically expressed in 44 GTEx tissues, estimated using partitioned h2SNP in LDSC; the help-seeking based definition of MDD (GPpsy), as well as its constituent no-MDD phenotype (GPNoDep), showed enrichment of h2SNP in genes specifically expressed in CNS tissues, similarly to an independent cohort of help-seeking-based MDD (23andMe4) and other psychiatric conditions such as bipolar disorder50, schizophrenia49, autism, personality dimension neuroticism, and the behavioral trait smoking. We indicate the sample size (n) for each definition of depression and psychiatric condition.